Vírus Linfotrópicos de células T humanas (HTLV-1 e HTLV-2): revisão de literatura / Human T-cell lymphotropic viruses (HTLV-1 and HTLV-2): literature review

نویسندگان

چکیده

Os vírus linfotrópicos de células T humanas (HTLV) foram os primeiros retrovírus potencialmente oncogênicos a serem descobertos e isolados no mundo. Estima-se que 15 20 milhões pessoas estejam infectadas pelo vírus. Até atualidade, quatro variantes descobertas descritas: HTLV-1, 2, 3 4. Destas, apenas o HTLV-1 2 parecem estar distribuídos globalmente, possuindo relevância clínica epidemiológica. O tem sido associado com Leucemia/Linfoma Células Adulto (LCTA) Mielopatia associada HTLV-1/ Paraparesia Espástica Tropical (HAM/PET), outras doenças também associadas ao patógeno. HTLV-2 apresenta menos patogenicidade, sendo paraparesia HTLV-2, neuropatias distúrbios da bexiga. A transmissão ocorre por meio contato célula-célula, vírion livre pouco eficiente, acontecendo principalmente vias: vertical — amamentação,via transplacentária ou canal parto —, sexual parenteral. prevenção se baseia em contraindicar amamentação mães sabidamente infectadas, uso camisinha nas relações sexuais evitar compartilhado agulhas seringas. diagnóstico é feito testes triagem (ELISA, aglutinação) confirmatórios (Western Blot, PCR). tratamento dependente forma doença na sintomatologia apresentada. Pacientes assintomáticos não devem ser tratados devido baixo risco desenvolvimento doença.

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ژورنال

عنوان ژورنال: Brazilian Journal of Health Review

سال: 2021

ISSN: ['2595-6825']

DOI: https://doi.org/10.34119/bjhrv4n5-193